Tom Brady and the Tampa Bay Buccaneers fell below .500 after a stunning 21-3 loss to the Carolina Panthers, who won their second game of the season Sunday despite playing a third-string quarterback and interim head coach.

Brady was 32 of 49 passing for 290 yards for the Bucks (3-4). One of those misses came when a wide open Mike Evans missed a 64-yard touchdown run on third down.

Brady hasn’t lost a game this far into the season since the New England Patriots lost four straight in 2002 to go 3-4.

PJ Walker threw for 177 yards and two touchdowns for Carolina (2-5) in place of the injured Baker Mayfield and Sam Darnold. The Panthers won for the first time under interim coach Steve Wilks, who replaced Matt Rhule when he was fired on Oct. 10.

Tampa Bay’s defense allowed the Panthers to rush for 173 yards. D’Onta Foreman ran for 118 yards and Chuba Hubbard added 63 yards and a touchdown.

Carolina is a 13 1/2 point underdog and has lost 12 of 13 games. They are now one game behind the Bucs and Atlanta Falcons for first place in the NFC South.

COMMANDERS 23, PACKERS 21

LANDOVER, Md. (AP) — Aaron Rodgers and the Green Bay offense sputtered, and Washington handed the Packers their third straight loss.

With a sore thumb and out of sync with his receivers, Rodgers was 23 of 35 for 194 yards and the Packers went 0 of 6 on third down. Green Bay (3-4) had just 232 rushing yards to Washington’s 364 and lost Allen Lazard to a shoulder injury, making him the third wide receiver on the team to go down during the first losing streak under coach Matt Lafleur .

Rodgers ended the game face down on the turf after a botched final play that ended with him throwing an onside kick out of bounds.

Washington’s front four also played a role in wearing Rodgers down and making him look more like a rookie than the 38-year-old four-time MVP. Only a series of penalties on the commanders (3-4) made the game closed in the last minutes.

Taylor Heinicke, making his first start of the season in place of the injured Carson Wentz, threw two touchdowns — including a perfect 37-yarder to Terry McLaurin — and was 20 of 33 for 200 yards.

Heinicke got off to a rough start, going 1-for-7 — including an interception that De’Vondr Campbell returned 63 yards for a touchdown.

GIANTS 23, JAGUARS 17

JACKSONVILLE, Fla. (AP) — Two New York defenders tackled Christian Kirk at the 1-yard line as time expired to preserve the win over Jacksonville.

The Giants are matching their best start since 2008. Quarterback Daniel Jones ran for a career-high 107 yards and a touchdown, turning to his feet to carry the Giants (6-1) down. He ran 35 yards on a pass and capped it off with a 1-yard rush after back-to-back Jacksonville penalties moved the ball inches from the goal line.

Jacksonville made one last drive and reached the New York 1-yard line on a Trevor Lawrence pass to Kirk. But Julian Love and Xavier McKinney stopped Kirk at the goal line even as Jaguars players tried to push the pile into the end zone.

Lawrence finished 22 of 43 for 310 yards as Jacksonville (2-5) lost its fourth straight.

Saquon Barkley finished with 107 yards on 24 carries and Graham Gano kicked three field goals for New York. The last Gano gave the Giants a chance to breathe.

KRUMKACHI 23, BROWN 20

BALTIMORE (AP) — Gus Edwards threw two touchdowns in his first game back from a serious knee injury, and Baltimore avoided another fourth-quarter slump thanks to a pair of big Cleveland penalties.

The Ravens (4-3) led 23-13 on Justin Tucker’s 55-yard field goal with 11:24 left, but the Browns answered with a 2-yard touchdown run by Kareem Hunt to make it a three-point game. Then a fumble by Baltimore’s Justice Hill gave Cleveland the ball at its own 16 with 3:12 to play.

With the Browns in charge, Amari Cooper was called for offensive pass interference, and a false start penalty on a field goal forced Cade York to try it from 60 yards out. His attempt was blocked by Malik Harrison with 1:59 left.

Cleveland (2-5) has lost four straight.

Edwards missed all of last season and the first six games of this one, but he rushed for 66 yards on a 7-and-1 drive that left Baltimore tied with Cincinnati atop the AFC North.

The Ravens’ Lamar Jackson was sacked three times and threw for just 120 yards. The Browns’ Jacoby Brissett was 22 of 27 for 258 yards, but he was sacked five times and fumbled one of them.

COWBOYS 24, LIONS 6

ARLINGTON, Texas (AP) — Ezekiel Elliott ran for two 1-yard touchdowns and Dak Prescott threw for a score in his return from injury as Dallas relied on its defense to beat Detroit.

The Cowboys (5-2) recovered Jamal Williams’ fumble at their 1 for a four-point lead early in the fourth quarter. Jared Goff was responsible for Detroit’s other four losses, with two interceptions and two fumbles lost.

Prescott was predictably cut short after missing five games with a broken right thumb. He was 19 of 25 for 207 yards, while Goff was 21 of 26 for 228 yards. Goff’s first three turnovers led to three Dallas touchdowns.

The Lions (1-5) got good three-quarter results from the NFL’s worst defense, but coach Dan Campbell fell to 0-11-1 on the road with the Lions.

Elliott had 57 yards on 15 carries and Tony Pollard rushed 12 times for 83 yards.

TITANS 19, COLTS 10

NASHVILLE, Tenn. (AP) — Andrew Adams threw an interception 76 yards for the first pick-six of his career and Tennessee never trailed, ending AFC South rival Indianapolis’ second straight sweep.

The two-time defending division champion Titans (4-2) won their fourth straight overall and have now beaten the Colts five straight.

Randy Bullock matched his career high with four field goals, the last two of which gave Tennessee its first points of the season in the fourth quarter. Bullock’s 48-yarder provided the final lead with 4:47 left.

The Titans had three turnovers, the last on a Michael Pittman Jr. fumble with 3:22 left. Jeffrey Simmons also had one of three sacks for Tennessee.

Derrick Henry helped seal the win with his third straight 100-yard game, finishing with a season-high 128 yards on 30 carries.

Matt Ryan went 33 of 44 for 243 yards and a touchdown, but was intercepted twice. The Colts (3-3-1) had their two-game winning streak ended.

BENGALS 35, FALCONS 17

CINCINNATI (AP) — Joe Barrow passed for 345 yards and three touchdowns in the first half as Cincinnati scored on its first four possessions and rolled past Atlanta.

The Cincinnati quarterback had his best game of the season, going 34-of-42 for 481 yards and three touchdowns and a rushing touchdown as the defending AFC champion Bengals (4-3) climbed above .500 for the first time this season.

Receivers Ja’Mar Chase and Tyler Boyd both eclipsed the 100-yard mark in the first half. Boyd finished with a career-high 155 yards on eight catches. Chase also caught eight passes for 130 yards and two touchdowns.

Marcus Mariota had just eight assists for the Falcons (3-4), whose strong running game was also stymied by Cincinnati. Mariota threw for 124 yards and Atlanta generated just 214 yards of offense to the Bengals’ 537 yards.

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