COVID-19 vaccine study links side effects to greater antibody response

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Video above: Doctor breaks down new data on COVID-19 vaccine from ModernaPeople reported side effects from Pfizer/BioNTech and Moderna’s COVID-19 vaccines, such as fever, chills, or muscle pain, tended to elicit greater antibody responses after vaccination. a new study. Having such symptoms after vaccination is associated with a greater antibody response compared with having only pain or a rash at the injection site, or no symptoms at all, suggests a paper published Friday in the journal JAMA Network Open. to redefine post-vaccination symptoms as signals of vaccine efficacy and strengthen recommendations for vaccine boosters in the elderly,” researchers from Columbia University in New York, the University of Vermont, and Boston University write in their paper. But even though some people may have few localized side effects or no symptoms at all, the vaccine still elicits strong immune responses in them. Almost all of the study participants showed a positive antibody response after two doses of the Pfizer/BioNTech or Moderna vaccine series. “I don’t want a patient to tell me : “God, I didn’t get any reaction, my hand doesn’t “It doesn’t hurt, I didn’t have a temperature. It didn’t work.’ people who had a reaction that their immune system was responding, actually quite well, to the vaccine, even though it caused them some discomfort,” Schaffner said. Video below: Doctors answer parents’ concerns about vaccinating their children. Researchers analyzed data from 928 adults who self-reported symptoms after receiving the Pfizer/BioNTech or Moderna vaccine against COVID-19, and who also submitted a dried blood spot for antibody testing. The majority of participants were white adults, with an average age of 65. The researchers found that after any vaccine dose, 446 or 48% of participants reported systemic symptoms, while 12% reported only local symptoms and 40% reported no symptoms at all. , antibody reactivity was observed in 444 or 99% of participants with systemic symptoms, 99% of participants with only local symptoms, and 98% of those with no symptoms.” Many people have wondered over the years whether people who had more A response to the vaccine may actually mean a more vigorous immune response,” Schaffner said. “And these data seem to support that.” Video below: Younger children experience fewer side effects from the COVID-19 vaccine

Video above: Doctor breaks down new data on Moderna’s COVID-19 vaccine

People who reported side effects from Pfizer/BioNTech and Moderna’s COVID-19 vaccines, such as fever, chills or muscle pain, had higher antibody responses after vaccination, according to new research.

The presence of such symptoms after vaccination is associated with a greater antibody response compared with having only pain or a rash at the injection site or no symptoms at all, suggests an article published Friday in the journal JAMA Open Network.

“In conclusion, these findings support a reinterpretation of postvaccination symptoms as signals of vaccine efficacy and strengthen recommendations for a vaccine booster in the elderly,” researchers from Columbia University in New York, the University of Vermont, and Boston University write in their paper.

But even though some people may have mild, localized side effects or no symptoms at all, the vaccine still causes strong immune responses in them. Almost all study participants demonstrated a positive antibody response after receiving two doses of either the Pfizer/BioNTech or Moderna series of vaccines.

“I don’t want a patient to say to me, ‘Oh my God, I didn’t have a reaction, my arm didn’t hurt, I didn’t have a temperature. The vaccine did not work.” I don’t want that to be the conclusion,” said Dr. William Schaffner, a professor of infectious diseases at Vanderbilt University Medical Center and medical director of the National Foundation for Infectious Diseases, who was not involved in the new study.

“It’s more to reassure people who have had a reaction that their immune system is responding, actually, quite well to the vaccine, even though it has caused them some discomfort,” Schaffner said.

Video below: Doctors answer parents’ concerns about vaccinating their children

Researchers analyzed data from 928 adults who self-reported symptoms they experienced after receiving the Pfizer/BioNTech or Moderna COVID-19 vaccines and provided a dried blood spot for antibody testing. The majority of participants were white adults, with a mean age of 65 years.

The researchers found that after any vaccine dose, 446 or 48% of participants reported systemic symptoms, while 12% reported only local symptoms and 40% reported no symptoms at all.

Meanwhile, antibody reactivity was observed in 444 or 99% of participants with systemic symptoms, 99% of participants with only local symptoms, and 98% of participants without symptoms.

“Over the years, a lot of people have speculated whether people who had a greater response to the vaccine might actually have a more vigorous immune response,” Schaffner said. “And this data seems to support that.”

Video below: Younger children experience fewer side effects from the COVID-19 vaccine

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